Last update :
12/06/2024
References   References 2361  
Type : Journal
Web link : https://doi.org/10.1111/j.1365-2710.2009.01043.x

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Lebitasy M, Hecq J.D, Athanassopoulos A, Vanbeckbergen D, Jamart J, Galanti L.
Title : Effect of freeze-thawing on the long-term stability of calcium levofolinate in 5% dextrose stored on polyolefin infusion bags.
Reference : J Clin Pharm Ther ; 34, 4 : 423-428. 2009

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionLevofolinate calcium Cytoprotective
Stability in solutions Polyethylene Glucose 5% 1,6 mg/ml -20°C Protect from light
95 Day
Stability in solutions Polyethylene Glucose 5% 1,6 mg/ml 2-8°C Protect from light
30 Day

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