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References   References 2289  
Type : Journal
Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Maas B, Huber C, Krämer I.
Title : Stabilität von bendamustinhydrochloride in infusion lösungen.
Reference : Pharmazie ; 49, 10: 775-777. 1994
Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
No visual inspection
Degradation products identified
Very unstable substance, difficult to achieve repeatability
List of drugs
InjectionBendamustine hydrochloride Anticancer drug
Factors which affect stability Temperature Increase Induces Degradation
Factors which affect stability [Cl-] Induces Enhanced stability
Stability in solutions Not specified Sodium chloride 0,9% 0,25 mg/ml 23°C Not specified
9 Hour
Stability in solutions Not specified Sodium chloride 0,9% 0,25 mg/ml 4°C Protect from light
4 Day
  Mentions Légales