Last update :
28/04/2024
References   References 2252  
Type : Journal

Research teams : San Francisco - Elan Pharmaceuticals Inc
Authors : Shields D, Montenegro R, Aclan J.
Title : Chemical stability of admixture combining ziconotide and bupivacaine during simulated intrathecal administration.
Reference : Neuromodulation ; 10, 1: 1-5. 2007

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
No visual inspection

List of drugs
InjectionBupivacaine hydrochloride Local anesthetic
InjectionZiconotide acetate Analgesic
Stability of mixtures
Not specified None 37°C Protect from light
Injection Ziconotide acetate 25 µg/ml
Injection Bupivacaine hydrochloride 5 mg/ml
22 Day

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