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References   References 2241  
Type : Journal
Web link : http://opp.sagepub.com/cgi/content/abstract/6/3/115
Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Thiesen J, Krämer I.
Title : Physicochemical stability of irinotecan injection concentrate and diluted infusion solutions in PVC bags.
Reference : J Oncol Pharm Practice ; 6, 3: 115-121. 2000
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Degradation products identified
List of drugs
InjectionIrinotecan Anticancer drug
Factors which affect stability Storage Light Induces Degradation
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 >> 2,8 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,4 >> 2,8 mg/ml 25°C Protect from light
28 Day
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