Last update :
18/04/2024
References   References 2214  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2684

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Ben M, Trusley C,Kupiec T.C, Trissel L.A.
Title : Palonosetron hydrochloride compatibility and stability with three beta-lactam antibiotics during simulated Y-site administration.
Reference : Int J Pharm Compound ; 11, 6: 520-524. 2007

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions

List of drugs
InjectionAmpicillin sodium - sulbactam sodium Antibiotic
Compatible 20/10 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Sodium chloride 0,9%
InjectionCefazolin sodium Antibiotic
Compatible 20 mg/ml + InjectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
InjectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + InjectionAmpicillin sodium - sulbactam sodium 20/10 mg/ml + Sodium chloride 0,9%
Compatible 50 µg/ml + InjectionCefazolin sodium 20 mg/ml + Glucose 5%
Stability of mixtures
Glass Sodium chloride 0,9% 25°C
Injection Ampicillin sodium - sulbactam sodium 20/10 mg/ml
Injection Palonosetron hydrochloride 25 µg/ml
4 Hour
Glass Glucose 5% 25°C
Injection Palonosetron hydrochloride 25 µg/ml
Injection Cefazolin sodium 10 mg/ml
4 Hour

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