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References   References 217  
Type : Journal
Research teams : Oklahoma City - University of Oklahoma Health Sciences Center, College of Pharmacy
Authors : Allen LV, Stiles ML, Wang DP, Tu YH.
Title : Stability of bupivacaine hydrochloride, epinephrine hydrochloride, and fentanyl citrate in portable infusion-pump reservoirs.
Reference : Am J Hosp Pharm ; 50: 714-715. 1993
Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Stability defined as 95% of the initial concentration
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Method not shown but the article refers to a validated method
List of drugs
InjectionBupivacaine hydrochloride Local anesthetic
InjectionEpinephrine hydrochloride Sympathomimetic
InjectionFentanyl citrate Analgesic
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 30°C Protect from light
Injection Bupivacaine hydrochloride 0,43 mg/ml
Injection Epinephrine hydrochloride 0,0006 µg/ml
Injection Fentanyl citrate 1,25 µg/ml
48 Hour
Polyvinyl chloride Sodium chloride 0,9% 3°C Protect from light
Injection Bupivacaine hydrochloride 0,43 mg/ml
Injection Epinephrine hydrochloride 0,0006 µg/ml
Injection Fentanyl citrate 1,25 µg/ml
20 Day
  Mentions Légales