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References   References 2117  
Type : Journal
Web link : https://doi.org/10.1345/aph.1G558
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Zhang Y, Trissel LA.
Title : Physical instability of frozen pemetrexed solutions in PVC bags.
Reference : Ann Pharmacotherapy ; 40, 7: 1289-1292. 2006
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
No comments for the degradation products
List of drugs
injectionPemetrexed disodium Anticancer drug
Factors which affect stability Temperature Polyvinyl chloride-20°C Induces Precipitation
  Mentions Légales