Last update :
15/04/2024
References   References 2113  
Type : Journal
Web link : http://springerlink.metapress.com/content/rh74033240673268/?p=e49f94994eca43c887197faa841dfc27&pi=6

Research teams : Kuopio - Kuopio University Hospital
Authors : Jäppinen A, Kokki H, Naaranlahti TJ, Rasi AS.
Title : Stability of buprenorphine, haloperidol and glycopyrrolate mixture in a 0.9% sodium chloride solution.
Reference : Pharm World Sci ; 21, 6: 272-274. 1999

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
InjectionBuprenorphine hydrochloride Analgesic
InjectionGlycopyrronium bromide Antimuscarinic
InjectionHaloperidol lactate Neuroleptic
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 21°C Protect from light
Injection Glycopyrronium bromide 15 mg/ml
Injection Haloperidol lactate 52 mg/ml
Injection Buprenorphine hydrochloride 57 mg/ml
30 Day
Polyvinyl chloride Sodium chloride 0,9% 36°C Protect from light
Injection Glycopyrronium bromide 15 mg/ml
Injection Haloperidol lactate 52 mg/ml
Injection Buprenorphine hydrochloride 57 mg/ml
9 Day
Polyvinyl chloride Sodium chloride 0,9% 4°C Protect from light
Injection Glycopyrronium bromide 15 mg/ml
Injection Haloperidol lactate 52 mg/ml
Injection Buprenorphine hydrochloride 57 mg/ml
30 Day
Polypropylene Sodium chloride 0,9% 21°C Protect from light
Injection Glycopyrronium bromide 15 mg/ml
Injection Haloperidol lactate 52 mg/ml
Injection Buprenorphine hydrochloride 57 mg/ml
30 Day
Polypropylene Sodium chloride 0,9% 36°C Protect from light
Injection Glycopyrronium bromide 15 mg/ml
Injection Haloperidol lactate 52 mg/ml
Injection Buprenorphine hydrochloride 57 mg/ml
16 Day
Polypropylene Sodium chloride 0,9% 4°C Protect from light
Injection Glycopyrronium bromide 15 mg/ml
Injection Haloperidol lactate 52 mg/ml
Injection Buprenorphine hydrochloride 57 mg/ml
30 Day

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