Last update :
03/05/2024
References   References 2103  
Type : Journal

Research teams : Valence - Universitat de Valencian Facultat de Quimica
Authors : Noguera Rodriguez A, Sancho Chust V, Medina Hernandez C, Medina Hernandez MJ, Jimenez Torrez NV.
Title : Estabilidad y compatibilidad del metamizol en jeringa y en mezclas intravenosas.
Reference : Farm Hosp ; 23: 103-108. 1999

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement Water loss by evaporation 
Comments : 
Repeatability / reproducibility / standard range: results not provided or results outside specified values
Stability indicating capability inadequately assessed

List of drugs
InjectionMetamizol sodium Analgesic
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 20 & 40 mg/ml 10°C Protect from light
5 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 20 & 40 mg/ml 24°C Protect from light
4 Day
Stability in solutions Polypropylen Syringe None 400 mg/ml 10 & 24°C Protect from light
10 Day

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