Last update :
18/04/2024
References   References 204  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/51/21/2693

Research teams : Baltimore - A.L Laboratories, Inc
Authors : Baaske DM, Dyskstra SD, Wagenknecht DM, Karnatz NN.
Title : Stability of esmolol hydrochloride in intravenous solutions.
Reference : Am J Hosp Pharm ; 51: 2693-2696. 1994

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 

List of drugs
InjectionEsmolol hydrochloride Beta-blocker
Factors which affect stability Solvent NaHCO3 Induces Reduced stability
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 23°C-27°C Light
7 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 10 mg/ml 5°C Protect from light
7 Day
Stability in solutions Glass Ringer’s lactate solution 10 mg/ml 23°C-27°C Light
7 Day
Stability in solutions Glass Ringer’s lactate solution 10 mg/ml 5°C Protect from light
7 Day
Stability in solutions Glass Sodium chloride 0,45% 10 mg/ml 23°C-27°C Light
7 Day
Stability in solutions Glass Sodium chloride 0,45% 10 mg/ml 5°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 23°C-27°C Light
7 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 10 mg/ml 5°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 10 mg/ml 23°C-27°C Light
7 Day
Stability in solutions Polyvinyl chloride Ringer’s lactate solution 10 mg/ml 5°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,45% 10 mg/ml 23°C-27°C Light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,45% 10 mg/ml 5°C Protect from light
7 Day

  Mentions Légales