Last update :
28/04/2024
References   References 2024  
Type : Journal
Web link : https://www.sciencedirect.com/science/article/pii/S088539240500237X

Research teams : Madrid - Universidad Complutense de Madrid,Facultad de Farmacia
Authors : Negro S, Martin A, Azuara ML, Sanchez Y, Barcia E.
Title : Stability of tramadol and haloperidol for continuous infusion at home.
Reference : J Pain Symptom Manage ; 30: 192-199. 2005

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Microscopic examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
Mass balance PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
InjectionHaloperidol lactate Neuroleptic
Compatible 0.208 >> 0.625 mg/ml + InjectionTramadol hydrochloride 8.33 >> 33.33 mg/ml + Sodium chloride 0,9%
InjectionTramadol hydrochloride Analgesic
Compatible 8.33 >> 33.33 mg/ml + InjectionHaloperidol lactate 0.208 >> 0.625 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylene Sodium chloride 0,9% 25°C Protect from light
Injection Tramadol hydrochloride 8,33 mg/ml
Injection Haloperidol lactate 0,208 mg/ml
15 Day
Polypropylene Sodium chloride 0,9% 25°C Protect from light
Injection Tramadol hydrochloride 33,33 mg/ml
Injection Haloperidol lactate 0,625 mg/ml
15 Day
Polypropylene Sodium chloride 0,9% 4°C Protect from light
Injection Tramadol hydrochloride 8,33 mg/ml
Injection Haloperidol lactate 0,208 mg/ml
15 Day
Polypropylene Sodium chloride 0,9% 4°C Protect from light
Injection Tramadol hydrochloride 33,33 mg/ml
Injection Haloperidol lactate 0,625 mg/ml
15 Day

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