Last update :
06/05/2024
References   References 1990  
Type : Journal

Research teams : Essen - Universitätklinikum, Apotheke
Authors : Hilger RA, Kredtke S, Barth J.
Title : Treosulfan : chemisch-physikalische stabilität, Hinweise für die pharmazeutisch-onkologische praxis.
Reference : Krankenhauspharmazie ; 11: 576-580. 2000

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
Degradation products identified and quantified
No visual inspection

List of drugs
InjectionTreosulfan Anticancer drug
Factors which affect stability Temperature 4°C Induces Precipitation
Factors which affect stability Temperature -20°C Induces Precipitation
Stability in solutions Glass Water for Injection 50 mg/ml 25°C Not specified
46 Day
Stability in solutions Glass Sodium chloride 0,9% 50 mg/ml 25°C Not specified
46 Day
Stability in solutions Glass Sodium chloride 0,45% 50 mg/ml 25°C Not specified
46 Day

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