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References   References 1976  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=2202
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Xu QA.
Title : Physical and chemical stability of palonosetron hydrochloride with topotecan hydrochloride and irinotecan hydrochloride during simulated Y-site administration.
Reference : Int J Pharm Compound ; 9, 3: 238-241. 2005
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
Comments : 
Degradation products not observed in real conditions
List of drugs
injectionIrinotecan Anticancer drug
Compatible 1 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
injectionPalonosetron hydrochloride Antiemetic
Compatible 50 µg/ml + injectionIrinotecan 1 mg/ml + Glucose 5%
Compatible 50 µg/ml + injectionTopotecan 0,1 mg/ml + Glucose 5%
injectionTopotecan Anticancer drug
Compatible 0,1 mg/ml + injectionPalonosetron hydrochloride 50 µg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 20°C-25°C Not specified
injection Palonosetron hydrochloride 25 µg/ml
injection Topotecan 0,05 mg/ml
4 Hour
Glass Glucose 5% 20°C-25°C Not specified
injection Palonosetron hydrochloride 25 µg/ml
injection Irinotecan 0,5 mg/ml
4 Hour
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