Last update :
28/04/2024
References   References 1929  
Type : Journal
Web link : https://doi.org/10.1016/j.jpba.2004.03.019

Research teams : Stockport - Stepping Hill Hospital, Quality Control North Wes
Authors : Rigge DC, Jones MF.
Title : Shelf lives of aseptically prepared medicines - stability of netilmicin injection in polypropylene syringes.
Reference : J Pharm Biomed Anal ; 35: 1251-1256. 2004

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Thin Layer Chromatography
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products
Changes in pH not commented or difficult to interpret

List of drugs
InjectionNetilmicin sulfate Antibiotic
Stability in solutions Polypropylen Syringe None 10 mg/ml 25°C Protect from light
9 Day
Stability in solutions Polypropylen Syringe None 10 & 100 mg/ml 7°C Protect from light
90 Day
Stability in solutions Polypropylen Syringe None 100 mg/ml 25°C Protect from light
30 Day

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