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References   References 191  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/45/10/2079
Research teams : Lawrence - The University of Kansas, Department of Pharmaceutical Chemistry
Authors : Riley CM.
Title : Stability of milrinone and digoxin, furosemide, procainamide hydrochloride, propranolol hydrochloride, quinidine gluconate, or verapamil hydrochloride in 5% dextrose injection.
Reference : Am J Hosp Pharm ; 45: 2079-2091. 1988
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionDigoxin Cardiotonic
Compatible 50 & 125 µg/ml + InjectionMilrinone lactate 0.1 & 0.35 mg/ml + Glucose 5%
InjectionFurosemide Diuretic
Incompatible 4 & 5 mg/ml + InjectionMilrinone lactate 0.100 & 0.350 mg/ml + Glucose 5%
InjectionMilrinone lactate Cardiotonic
Compatible 0.1 & 0.35 mg/ml + InjectionDigoxin 50 & 125 µg/ml + Glucose 5%
Incompatible 0.100 & 0.350 mg/ml + InjectionFurosemide 4 & 5 mg/ml + Glucose 5%
Incompatible 0.175 & 0.200 mg/ml + InjectionProcainamide hydrochloride 1 >> 4 mg/ml + Glucose 5%
Compatible 0.100 & 0.350 mg/ml + InjectionPropranolol hydrochloride 0.3 & 0.5 mg/ml + Glucose 5%
Compatible 0.175 & 0.200 mg/ml + InjectionQuinidine gluconate 5 & 10 mg/ml + Glucose 5%
Compatible 0.100 & 0.350 mg/ml + InjectionVerapamil hydrochloride 1 & 1.25 mg/ml + Glucose 5%
InjectionProcainamide hydrochloride Anti-arrhythmic
Incompatible 1 >> 4 mg/ml + InjectionMilrinone lactate 0.175 & 0.200 mg/ml + Glucose 5%
InjectionPropranolol hydrochloride Beta-blocker
Compatible 0.3 & 0.5 mg/ml + InjectionMilrinone lactate 0.100 & 0.350 mg/ml + Glucose 5%
InjectionQuinidine gluconate Anti-arrhythmic
Compatible 5 & 10 mg/ml + InjectionMilrinone lactate 0.175 & 0.200 mg/ml + Glucose 5%
InjectionVerapamil hydrochloride Anti-arrhythmic
Compatible 1 & 1.25 mg/ml + InjectionMilrinone lactate 0.100 & 0.350 mg/ml + Glucose 5%
Stability of mixtures
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,1 mg/ml
Injection Digoxin 125 µg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,35 mg/ml
Injection Digoxin 50 µg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,35 mg/ml
Injection Propranolol hydrochloride 0,3 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,1 mg/ml
Injection Propranolol hydrochloride 0,5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,175 mg/ml
Injection Quinidine gluconate 5 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,2 mg/ml
Injection Quinidine gluconate 10 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,35 mg/ml
Injection Verapamil hydrochloride 1 mg/ml
4 Hour
Glass Glucose 5% 22°C-23°C Light
Injection Milrinone lactate 0,1 mg/ml
Injection Verapamil hydrochloride 1,25 mg/ml
4 Hour
  Mentions Légales