Last update :
28/02/2024
References   References 1840  
Type : Journal

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Xu QA, Trissel LA, Saenz CA et al.
Title : Stability of three cephalosporin antibiotics in autodose infusion system bags.
Reference : J Am Pharm Assoc ; 42: 428-431. 2002

Level of Evidence : 
Level of evidence B+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
No comments for the degradation products

List of drugs
InjectionCefazolin sodium Antibiotic
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 10 mg/ml 23°C Protect from light
5 Day
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 10 mg/ml 4°C Protect from light
30 Day
InjectionCeftazidime Antibiotic
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 20 mg/ml 23°C Protect from light
24 Hour
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 20 mg/ml 4°C Protect from light
7 Day
InjectionCeftriaxone disodium Antibiotic
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 10 & 20 mg/ml 23°C Protect from light
3 Day
Stability in solutions Ethylene vinyl acetate Sodium chloride 0,9% 10 & 20 mg/ml 4°C Protect from light
30 Day

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