Last update :
12/06/2024
References   References 1835  
Type : Journal

Research teams : Kuopio - Kuopio University Hospital
Authors : Jäppinen A, Turpeinen M, Kokki H, ,Rasi A, Ojanen T, Pelkonen O, Naaranlahti T.
Title : Stability of sufentanil and levobupivacain solutions and a mixture in a 0.9% sodium chloride infusion stored in polypropylene syringes.
Reference : Eur J Pharm Sci ; 19, 1: 31-36. 2003

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point

List of drugs
InjectionLevobupivacaine hydrochloride Local anesthetic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 21°C Protect from light
28 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 36°C Protect from light
23 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 1 mg/ml 4°C Protect from light
28 Day
Compatible 1 mg/ml + InjectionSufentanil citrate 0.001 mg/ml + Sodium chloride 0,9%
InjectionSufentanil citrate Analgesic
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,001 mg/ml 21°C Protect from light
3 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,001 mg/ml 36°C Protect from light
1 Day
Stability in solutions Polypropylen Syringe Sodium chloride 0,9% 0,001 mg/ml 4°C Protect from light
23 Day
Compatible 0.001 mg/ml + InjectionLevobupivacaine hydrochloride 1 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polypropylen Syringe Sodium chloride 0,9% 21°C Protect from light
Injection Sufentanil citrate 0,00113 mg/ml
Injection Levobupivacaine hydrochloride 1,22 mg/ml
28 Day
Polypropylen Syringe Sodium chloride 0,9% 36°C Protect from light
Injection Sufentanil citrate 0,00113 mg/ml
Injection Levobupivacaine hydrochloride 1,22 mg/ml
28 Day
Polypropylen Syringe Sodium chloride 0,9% 4°C Protect from light
Injection Sufentanil citrate 0,00113 mg/ml
Injection Levobupivacaine hydrochloride 1,22 mg/ml
28 Day

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