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References   References 1685  
Type : Journal
Research teams : Friedberg - Fresenius Kabi, Innovation Centre i.v. Therapies
Authors : Müller H-J, Berg J.
Title : Stabilitätsstudie zu metamizol-natrium im PVC-infusionbeutel.
Reference : Krankenhauspharmazie ; 19: 229-234. 1998
Level of Evidence : 
Level of evidence A+
Physical stability : 
Particle counting Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionMetamizol sodium Analgesic
Factors which affect stability Storage Light Induces Degradation
Factors which affect stability Temperature Increase Induces Degradation
Factors which affect stability Concentration Increase Induces Enhanced stability
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 60 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 60 mg/ml 25°C Light
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 60 mg/ml 40°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 60 mg/ml 25°C Protect from light
14 Day
  Mentions Légales