Last update :
28/04/2024
References   References 1668  
Type : Journal
Web link : https://doi.org/10.1345/aph.10018

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Zhang Y, Xu QA, Trissel LA, Williams KY.
Title : Compatibility and stability of linezolid injection admixed with three quinolone antibiotics.
Reference : Ann Pharmacotherapy ; 34: 996-1001. 2000

Level of Evidence : 
Level of evidence C+
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
Comments : 
Increased concentration unexplained

List of drugs
InjectionCiprofloxacin lactate Antibiotic
Compatible 4 mg/ml + InjectionLinezolid 2 mg/ml + None
InjectionLevofloxacine Antibiotic
Compatible 5 mg/ml + InjectionLinezolid 2 mg/ml + None
InjectionLinezolid Antibiotic
Compatible 2 mg/ml + InjectionCiprofloxacin lactate 4 mg/ml + None
Compatible 2 mg/ml + InjectionLevofloxacine 5 mg/ml + None
Compatible 2 mg/ml + InjectionOfloxacin 4 mg/ml + None
InjectionOfloxacin Antibiotic
Compatible 4 mg/ml + InjectionLinezolid 2 mg/ml + None
Stability of mixtures
Polyolefine None 23°C Protect from light
Injection Linezolid 2 mg/ml
Injection Ciprofloxacin lactate 4 mg/ml
7 Day
Polyolefine None 23°C Protect from light
Injection Linezolid 2 mg/ml
Injection Levofloxacine 5 mg/ml
7 Day
Polyolefine None 23°C Protect from light
Injection Linezolid 2 mg/ml
Injection Ofloxacin 4 mg/ml
7 Day
Polyolefine None 4°C Protect from light
Injection Linezolid 2 mg/ml
Injection Levofloxacine 5 mg/ml
7 Day
Polyolefine None 4°C Protect from light
Injection Linezolid 2 mg/ml
Injection Ofloxacin 4 mg/ml
7 Day
Polyolefine None 4°C Protect from light
Injection Linezolid 2 mg/ml
Injection Ciprofloxacin lactate 4 mg/ml
24 Hour

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