Last update :
03/05/2024
References   References 1661  
Type : Journal
Web link : http://opp.sagepub.com/cgi/content/abstract/8/1/27

Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, King KM, Zhang Y, Wood AM.
Title : Physical and chemical stability of methotrexate, cytarabine, and hydrocortisone in Elliott’s B Solution for intrathecal use.
Reference : J Oncol Pharm Practice ; 8: 27-32. 2002

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination Turbidimetry Particle counting 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
InjectionCytarabine Anticancer drug
InjectionHydrocortisone sodium succinate Anti-inflammatory
InjectionMethotrexate sodium Anticancer drug
Stability of mixtures
Glass Elliott’s B solution 23°C Not specified
Injection Methotrexate sodium 0,0279 mg/ml
Injection Cytarabine 0,442 mg/ml
48 Hour
Glass Elliott’s B solution 23°C Not specified
Injection Methotrexate sodium 0,0314 mg/ml
Injection Cytarabine 0,484 mg/ml
Injection Hydrocortisone sodium succinate 0,478 mg/ml
48 Hour
Glass Elliott’s B solution 23°C Not specified
Injection Methotrexate sodium 0,0581 mg/ml
Injection Cytarabine 0,477 mg/ml
Injection Hydrocortisone sodium succinate 0,467 mg/ml
48 Hour
Glass Elliott’s B solution 23°C Not specified
Injection Methotrexate sodium 0,0542 mg/ml
Injection Cytarabine 0,433 mg/ml
48 Hour
Glass Elliott’s B solution 23°C Not specified
Injection Methotrexate sodium 0,0721 mg/ml
Injection Cytarabine 0,479 mg/ml
Injection Hydrocortisone sodium succinate 0,489 mg/ml
48 Hour
Glass Elliott’s B solution 23°C Not specified
Injection Methotrexate sodium 0,0649 mg/ml
Injection Cytarabine 0,431 mg/ml
48 Hour
Glass Elliott’s B solution 4°C Not specified
Injection Methotrexate sodium 0,0314 mg/ml
Injection Cytarabine 0,484 mg/ml
Injection Hydrocortisone sodium succinate 0,478 mg/ml
48 Hour
Glass Elliott’s B solution 4°C Not specified
Injection Methotrexate sodium 0,0279 mg/ml
Injection Cytarabine 0,442 mg/ml
48 Hour
Glass Elliott’s B solution 4°C Not specified
Injection Methotrexate sodium 0,0581 mg/ml
Injection Cytarabine 0,477 mg/ml
Injection Hydrocortisone sodium succinate 0,467 mg/ml
48 Hour
Glass Elliott’s B solution 4°C Not specified
Injection Methotrexate sodium 0,0542 mg/ml
Injection Cytarabine 0,433 mg/ml
48 Hour
Glass Elliott’s B solution 4°C Not specified
Injection Methotrexate sodium 0,0721 mg/ml
Injection Cytarabine 0,479 mg/ml
Injection Hydrocortisone sodium succinate 0,489 mg/ml
48 Hour
Glass Elliott’s B solution 4°C Not specified
Injection Methotrexate sodium 0,0649 mg/ml
Injection Cytarabine 0,431 mg/ml
48 Hour

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