Last update :
22/01/2021
References   References 164  
Type : Journal

Research teams : Lille - Faculté des Sciences Pharmaceutiques et Biologiques
Authors : Benaji B, Dine T, Luyckx M, Brunet C, Goudaliez F, Mallevais ML, Cazin M, Gressier B, Cazin JC.
Title : Stability and compatibility of cisplatin and carboplatin with PVC infusion bags.
Reference : J Clin Pharm Ther ; 19: 95-100. 1994

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Degradation products not observed in real conditions

List of drugs
InjectionCarboplatin Anticancer drug
Stability in solutions Polyvinyl chloride Glucose 5% 2,4 mg/ml 20°C-24°C Protect from light
9 Day
InjectionCisplatin Anticancer drug
Factors which affect stability Temperature 4°C[ > 0,5 mg / ml] Induces Precipitation
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,6 mg/ml 20°C-24°C Protect from light
9 Day

  Mentions Légales