Last update :
03/05/2024
References   References 1606  
Type : Journal

Research teams : Bethesda - National Institutes of Health Clinical Center
Authors : Yuan P, Grimes GJ, Shankman SE, Daniels CE, Goldspiel BR, Potti GK.
Title : Compatibility and stability of vincristine sulfate, doxorubicin hydrochloride, and etoposide phosphate in 0.9% sodium chloride injection.
Reference : Am J Health-Syst Pharm ; 58: 594-598. 2001

Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products detected but not quantified

List of drugs
InjectionDoxorubicin hydrochloride Anticancer drug
InjectionEtoposide phosphate Anticancer drug
InjectionVincristine sulfate Anticancer drug
Stability of mixtures
Polyolefine Sodium chloride 0,9% 2-6°C Protect from light
Injection Doxorubicin hydrochloride 0,12 mg/ml
Injection Etoposide phosphate 0,6 mg/ml
Injection Vincristine sulfate 0,005 mg/ml
5 Day
Polyolefine Sodium chloride 0,9% 2-6°C Protect from light
Injection Doxorubicin hydrochloride 0,24 mg/ml
Injection Etoposide phosphate 1,2 mg/ml
Injection Vincristine sulfate 0,010 mg/ml
5 Day
Polyolefine Sodium chloride 0,9% 2-6°C With or without light
Injection Doxorubicin hydrochloride 0,4 mg/ml
Injection Etoposide phosphate 2 mg/ml
Injection Vincristine sulfate 0,016 mg/ml
5 Day
Polyolefine Sodium chloride 0,9% 35°C-40°C Protect from light
Injection Doxorubicin hydrochloride 0,12 mg/ml
Injection Etoposide phosphate 0,6 mg/ml
Injection Vincristine sulfate 0,005 mg/ml
5 Day
Polyolefine Sodium chloride 0,9% 35°C-40°C Protect from light
Injection Doxorubicin hydrochloride 0,24 mg/ml
Injection Etoposide phosphate 1,2 mg/ml
Injection Vincristine sulfate 0,010 mg/ml
5 Day
Polyolefine Sodium chloride 0,9% 35°C-40°C With or without light
Injection Doxorubicin hydrochloride 0,4 mg/ml
Injection Etoposide phosphate 2 mg/ml
Injection Vincristine sulfate 0,016 mg/ml
5 Day

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