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References   References 1603  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/58/13/1218
Research teams : West Point - Merck and Co
Authors : Bergquist PA, Manas D, Hunke WA, Reed RA.
Title : Stability and compatibility of tirofiban hydrochloride during simulated Y-site administration with other drugs.
Reference : Am J Health-Syst Pharm ; 58: 1218-1223. 2001
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
List of drugs
InjectionAtropine sulfate Antimuscarinic
Compatible 0,4 & 1 mg/ml + InjectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
InjectionDiazepam Anxiolytic
Incompatible 5 mg/ml + InjectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
InjectionDobutamine hydrochloride Cardiotonic
Compatible 0,25 & 5 mg/ml + InjectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
InjectionEpinephrine hydrochloride Sympathomimetic
Compatible 2 & 100 µg/ml + InjectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
InjectionFurosemide Diuretic
Compatible 0,5 & 10 mg/ml + InjectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
InjectionMidazolam hydrochloride Anxiolytic
Compatible 0,05 & 5 mg/ml + InjectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
InjectionMorphine sulfate Analgesic
Compatible 0,1 & 1 mg/ml + InjectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
InjectionNitroglycerin Vasodilator
Compatible 0,1 & 0,4 mg/ml + InjectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
InjectionPropranolol hydrochloride Beta-blocker
Compatible 1 mg/ml + InjectionTirofiban 50 µg/ml + NaCl 0,9% or Glucose 5%
InjectionTirofiban Anticoagulant
Compatible 50 µg/ml + InjectionAtropine sulfate 0,4 & 1 mg/ml + NaCl 0,9% or Glucose 5%
Incompatible 50 µg/ml + InjectionDiazepam 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + InjectionDobutamine hydrochloride 0,25 & 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + InjectionEpinephrine hydrochloride 2 & 100 µg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + InjectionFurosemide 0,5 & 10 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + InjectionMidazolam hydrochloride 0,05 & 5 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + InjectionMorphine sulfate 0,1 & 1 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + InjectionNitroglycerin 0,1 & 0,4 mg/ml + NaCl 0,9% or Glucose 5%
Compatible 50 µg/ml + InjectionPropranolol hydrochloride 1 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
Injection Tirofiban 50 µg/ml
Injection Atropine sulfate 0,4 & 1 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
Injection Tirofiban 50 µg/ml
Injection Dobutamine hydrochloride 0,25 & 5 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
Injection Tirofiban 50 µg/ml
Injection Epinephrine hydrochloride 2 & 100 µg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
Injection Tirofiban 50 µg/ml
Injection Furosemide 0,5 & 10 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
Injection Tirofiban 50 µg/ml
Injection Midazolam hydrochloride 0,05 & 5 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
Injection Tirofiban 50 µg/ml
Injection Morphine sulfate 0,1 & 1 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
Injection Tirofiban 50 µg/ml
Injection Nitroglycerin 0,1 & 0,4 mg/ml
4 Hour
Glass NaCl 0,9% or Glucose 5% 20°C-25°C Light
Injection Tirofiban 50 µg/ml
Injection Propranolol hydrochloride 1 mg/ml
4 Hour
  Mentions Légales