Last update :
28/04/2024
References   References 160  
Type : Journal

Research teams : Montpellier - Oncopharmacology Laboratory, Val D'Aurelle Cancer Center
Authors : Pinguet F, Martel P, Rouanet P, Fabbro M, Astre C.
Title : Effect of sodium chloride concentration and temperature on melphalan stability during storage and use.
Reference : Am J Hosp Pharm ; 51: 2701-2704. 1994

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
InjectionMelphalan Anticancer drug
Factors which affect stability Solvent Sodium chloride 3% Induces Enhanced stability
Factors which affect stability Temperature Increase Induces Degradation
Stability in solutions Polyvinyl chloride Water for Injection 0,2 mg/ml -20°C Protect from light
72 Hour
Stability in solutions Polyvinyl chloride Water for Injection 0,2 mg/ml 4°C Protect from light
6 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,2 mg/ml -20°C Protect from light
72 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 0,2 mg/ml 4°C Protect from light
6 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 3% 0,2 mg/ml -20°C Protect from light
72 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 3% 0,2 mg/ml 20°C Light
12 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 3% 0,2 mg/ml 23°C Light
5 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 3% 0,2 mg/ml 26°C Light
3 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 3% 0,2 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 3% 2 mg/ml 23°C Light
4 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 3% 2 mg/ml 26°C Light
3 Hour

  Mentions Légales