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References   References 1425  
Type : Journal
Web link : http://opp.sagepub.com/cgi/content/abstract/5/2/75
Research teams : Mainz - University Medical Center, Johannes Gutenberg
Authors : Krämer I, Thiesen J.
Title : Stability of topotecan infusion solutions in polyvinylchloride bags and elastomeric portable infusion devices.
Reference : J Oncol Pharm Practice ; 5: 75-82. 1999
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products
List of drugs
InjectionTopotecan Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Glass Water for Injection 1 mg/ml 25°C Protect from light
28 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 25°C Protect from light
28 Day
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 2-8°C Protect from light
28 Day
Stability in solutions Polyisoprene elastomer NaCl 0,9% or Glucose 5% 0,01 >> 0,05 mg/ml 25°C Protect from light
28 Day
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