Last update :
03/05/2024
References   References 1408  
Type : Journal PC : 0.0006830601092896 

Research teams : Plymouth - Derriford Hospital,Department of Pharmacy
Authors : Priston MJ, Sewell GJ.
Title : Stability of three cytotoxic drugs infusions in the Graseby 9000 ambulatory infusion pump.
Reference : J Oncol Pharm Practice ; 4: 143-149. 1998

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Other methods : 
PH measurement Search of DEHP Mass balance 
Comments : 
No comments for the degradation products

List of drugs
InjectionDoxorubicin hydrochloride Anticancer drug
InjectionIfosfamide Anticancer drug
InjectionMesna Cytoprotective
InjectionVincristine sulfate Anticancer drug
Stability of mixtures
Polyvinyl chloride Water for Injection 37°C Protect from light
Injection Doxorubicin hydrochloride 2 mg/ml
Injection Vincristine sulfate 0,2 mg/ml
7 Day
Polyvinyl chloride Water for Injection 37°C Protect from light
Injection Ifosfamide 20 mg/ml
Injection Mesna 20 mg/ml
7 Day
Polyvinyl chloride Water for Injection 8°C Protect from light
Injection Doxorubicin hydrochloride 2 mg/ml
Injection Vincristine sulfate 0,2 mg/ml
14 Day
Polyvinyl chloride Water for Injection 8°C Protect from light
Injection Ifosfamide 20 mg/ml
Injection Mesna 20 mg/ml
14 Day

  Mentions Légales