Last update :
20/01/2021
References   References 133  
Type : Journal

Research teams : Oklahoma City - University of Oklahoma Health Sciences Center, College of Pharmacy
Authors : Allen LV Jr, Stiles ML, Prince SJ, Smeeding J.
Title : Stability of 14 drugs in the latex reservoir of an elastomeric infusion device.
Reference : Am J Health-Syst Pharm ; 53: 2740-2743. 1996

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Degradation products detected but not quantified
No visual inspection

List of drugs
InjectionAmpicillin sodium Antibiotic
Stability in solutions Elastomer Sodium chloride 0,9% 20 mg/ml 25°C Not specified
8 Hour
Stability in solutions Elastomer Sodium chloride 0,9% 20 mg/ml 5°C Protect from light
3 Day
InjectionCefazolin sodium Antibiotic
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml -20°C Protect from light
84 Day
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Not specified
24 Hour
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml 5°C Protect from light
7 Day
InjectionCeftazidime Antibiotic
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml -20°C Protect from light
84 Day
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Not specified
18 Hour
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml 5°C Protect from light
7 Day
InjectionCeftriaxone disodium Antibiotic
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml -20°C Protect from light
182 Day
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Not specified
72 Hour
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml 5°C Protect from light
10 Day
InjectionDoxorubicin hydrochloride Anticancer drug
Stability in solutions Elastomer Sodium chloride 0,9% 2 mg/ml 25°C Not specified
24 Hour
Stability in solutions Elastomer Sodium chloride 0,9% 2 mg/ml 5°C Protect from light
2 Day
InjectionFluorouracil Anticancer drug
Stability in solutions Elastomer Sodium chloride 0,9% 5 mg/ml 25°C Not specified
24 Hour
InjectionGanciclovir sodium Antiviral
Stability in solutions Elastomer Sodium chloride 0,9% 5 mg/ml 25°C Not specified
24 Hour
Stability in solutions Elastomer Sodium chloride 0,9% 5 mg/ml 5°C Protect from light
5 Day
InjectionGentamicin sulfate Antibiotic
Stability in solutions Elastomer Sodium chloride 0,9% 0,8 mg/ml 25°C Not specified
24 Hour
InjectionImipenem - cilastatin sodium Antibiotic
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 5 mg/ml 25°C Not specified
4 Hour
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 5 mg/ml 5°C Protect from light
24 Hour
InjectionNafcillin sodium Antibiotic
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml -20°C Protect from light
84 Day
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml 25°C Not specified
24 Hour
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 20 mg/ml 5°C Protect from light
4 Day
InjectionPiperacillin sodium Antibiotic
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 30 mg/ml -20°C Protect from light
28 Day
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 30 mg/ml 25°C Not specified
24 Hour
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 30 mg/ml 5°C Protect from light
7 Day
InjectionTobramycin sulfate Antibiotic
Stability in solutions Elastomer Sodium chloride 0,9% 0,8 mg/ml 25°C Not specified
24 Hour
InjectionVancomycin hydrochloride Antibiotic
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 5 mg/ml -20°C Protect from light
63 Day
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 5 mg/ml 25°C Not specified
24 Hour
Stability in solutions Elastomer NaCl 0,9% or Glucose 5% 5 mg/ml 5°C Protect from light
14 Day

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