Last update :
03/05/2024
InfoStab
Infostab
List of drugs
List of drugs
Summary lists
Summary lists
Search for compatibilities
Search for compatibilities
Y-site compatibility table
Y-site compatibility table
References
References
Research teams
Research teams
Valistab
Valistab
Poster
Poster
Links
Links
Sponsors
Sponsors
Authors
Authors
User’s guide
User’s guide
Newsletter
Newsletter
References   References 1286  
Type : Journal
Web link : https://doi.org/10.1345/aph.17400
Research teams : Houston - M.D.Anderson Cancer Center
Authors : Trissel LA, Xu QA, Gilbert DL.
Title : Compatibility and stability of paclitaxel combined with doxorubicin hydrochloride in infusion solutions.
Reference : Ann Pharmacotherapy ; 32: 1013-1016. 1998
Level of Evidence : 
Joker
Level of Evidence : 
Level of evidence A+ Paclitaxel
Level of evidence B+ Doxorubicin hydrochloride
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
Stability defined as 90% of the initial concentrationDoxorubicin hydrochloride
Stability defined as 95% of the initial concentrationPaclitaxel
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Paclitaxel
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)Doxorubicin hydrochloride
Other methods : 
Comments : 
No comments for the degradation productsPaclitaxel
No comments for the degradation productsDoxorubicin hydrochloride
List of drugs
InjectionDoxorubicin hydrochloride Anticancer drug
Compatible 0,2 mg/ml + InjectionPaclitaxel 0,3 & 1,2 mg/ml + NaCl 0,9% or Glucose 5%
InjectionPaclitaxel Anticancer drug
Compatible 0,3 & 1,2 mg/ml + InjectionDoxorubicin hydrochloride 0,2 mg/ml + NaCl 0,9% or Glucose 5%
Stability of mixtures
Polyolefine NaCl 0,9% or Glucose 5% 23°C Light
Injection Doxorubicin hydrochloride 0,2 mg/ml
Injection Paclitaxel 0,3 & 1,2 mg/ml
24 Hour
Polyolefine NaCl 0,9% or Glucose 5% 32°C Light
Injection Paclitaxel 0,3 & 1,2 mg/ml
Injection Doxorubicin hydrochloride 0,2 mg/ml
24 Hour
Polyolefine NaCl 0,9% or Glucose 5% 4°C Protect from light
Injection Paclitaxel 0,3 & 1,2 mg/ml
Injection Doxorubicin hydrochloride 0,2 mg/ml
24 Hour
  Mentions Légales