Last update :
18/04/2024
References   References 1278  
Type : Journal

Research teams : Toronto - Sunnybrook Health Sciences Center
Authors : Walker SE, Dufour A, Iazetta J.
Title : Concentration and solution dependent stability of cloxacillin intravenous solutions.
Reference : Can J Hosp Pharm ; 51: 13-19. 1998

Level of Evidence : 
Level of evidence B
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 90% of the initial concentration
Other methods : 
Measurement of osmolality PH measurement 
Comments : 

List of drugs
InjectionCloxacillin sodium Antibiotic
Factors which affect stability Solvent Glucose 5% Induces Enhanced stability
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 5 >> 50 mg/ml 4°C Protect from light
7 Day
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 5 >> 50 mg/ml 23°C Not specified
1 Day
Stability in solutions Polyvinyl chloride Glucose 5% 5 >> 40 mg/ml 23°C Not specified
4 Day
Stability in solutions Polyvinyl chloride Glucose 5% 50 mg/ml 23°C Not specified
2 Day

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