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References   References 1277  
Type : Journal
Research teams : Ottawa - The Ottawa Hospital, department of Pharmacy
Authors : Donnelly RF.
Title : Chemical stability of diphenhydramine hydrochloride in minibags and polypropylene syringes.
Reference : Can J Hosp Pharm ; 52: 150-155. 1999
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions
List of drugs
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,25 & 0,5 & 1 mg/ml 22°C Protect from light
91 Day
Stability in solutions Polyvinyl chloride NaCl 0,9% or Glucose 5% 0,25 & 0,5 & 1 mg/ml 4°C Protect from light
91 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 1,25 & 2,5 & 5 mg/ml 22°C Protect from light
28 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 1,25 & 2,5 & 5 mg/ml 4°C Protect from light
28 Day
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