Last update :
03/05/2024
References   References 1115  
Type : Journal

Research teams : Mac Gaw Park - American Critical Care
Authors : Baaske DM, Malick AW, Carter JE.
Title : Stability of procainamide hydrochloride in dextrose solutions.
Reference : Am J Hosp Pharm ; 37: 1050-1052. 1980

Level of Evidence : 
Level of evidence D
Physical stability : 
Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied

List of drugs
InjectionProcainamide hydrochloride Anti-arrhythmic
Factors which affect stability Solvent Glucose 5% Induces Degradation
Stability in solutions Glass Water for Injection 4 mg/ml 25°C Not specified
48 Hour
Stability in solutions Glass Water for Injection 4 mg/ml 4°C Protect from light
7 Day
Incompatible + Glucose 5%

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