Last update :
21/02/2024
References   References 10  
Type : Journal
Web link : http://www.ajhp.org/cgi/content/abstract/54/4/412

Research teams : Wilmington - Zeneca Pharma
Authors : Patel PR, Cook SE.
Title : Stability of meropenem in intravenous solutions.
Reference : Am J Health-Syst Pharm ; 54: 412-421. 1997

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Repeatability / reproducibility / standard range: results not provided or results outside specified values
No visual inspection
No comments for the degradation products

List of drugs
InjectionMeropenem Antibiotic
Stability in solutions Glass Water for Injection 2,5 mg/ml 21°C-26°C Not specified
24 Hour
Stability in solutions Glass Water for Injection 2,5 & 50 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Glass Water for Injection 50 mg/ml 21-26°C Not specified
8 Hour
Stability in solutions Glass Sodium chloride 0,9% 2,5 mg/ml 21-26°C Not specified
24 Hour
Stability in solutions Glass Sodium chloride 0,9% 2,5 & 50 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Glass Sodium chloride 0,9% 50 mg/ml 21-26°C Not specified
8 Hour
Stability in solutions Glass Glucose 5% 2,5 & 50 mg/ml 21-26°C Not specified
3 Hour
Stability in solutions Glass Glucose 5% 2,5 & 50 mg/ml 4°C Protect from light
24 Hour
Stability in solutions Polyvinyl chloride Water for Injection 1 mg/ml 21-26°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Water for Injection 1 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polyvinyl chloride Water for Injection 20 mg/ml 21-26°C Not specified
10 Hour
Stability in solutions Polyvinyl chloride Water for Injection 20 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 mg/ml 21°C-26°C Not specified
24 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 1 & 20 mg/ml 4°C Protect from light
48 Hour
Stability in solutions Polyvinyl chloride Sodium chloride 0,9% 20 mg/ml 21-26°C Not specified
10 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 1 mg/ml 21-26°C Not specified
4 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 1 mg/ml 4°C Protect from light
18 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 20 mg/ml 21-26°C Not specified
3 Hour
Stability in solutions Polyvinyl chloride Glucose 5% 20 mg/ml 4°C Protect from light
16 Hour

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