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References   References 504  
Type : Journal
Research teams : Châtenay-Malabry - Faculté de pharmacie de Paris Sud
Authors : Hamon M, Plas-Remoissenet D, Kubab-Alajati S.
Title : Etude de la stabilité dans des solutions diluées destinées à la perfusion de deux antimitotiques dérivés de la podophyllotoxine : l’étoposide (VP 16), le téniposide (VM 26).
Reference : Sci Tech Pharm ; 3: 33-40. 1987
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
Thin Layer Chromatography
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Gas chromatography
Other methods : 
Search of DEHP 
Comments : 
Degradation products identified and quantified
List of drugs
injectionEtoposide Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 0,2 mg/ml ? Not specified
7 Day
Stability in solutions Glass Glucose 5% 0,2 mg/ml ? Not specified
7 Day
injectionTeniposide Anticancer drug
Stability in solutions Glass Sodium chloride 0,9% 0,1 mg/ml ? Not specified
5 Hour
Stability in solutions Glass Glucose 5% 0,1 mg/ml ? Not specified
5 Hour
  Mentions Légales