Last update :
05/12/2025
References   References 481  
Type : Journal PC : 0.0006830601092896 

Research teams : Utrecht - Faculty of pharmacy, State university of Utrecht
Authors : Beijnen JH, Vendrig DEMM, Underberg WJM.
Title : Stability of vinca alkaloid anticancer drugs in three commonly used infusion fluids.
Reference : J Parenter Sci Technol ; 43: 84-87. 1989

Level of Evidence : 
Level of evidence B
Physical stability : 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
Comments : 
No visual inspection
No comments for the degradation products

List of drugs
injectionVinblastine sulfate Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 4°C Protect from light
21 Day
Compatible + Ringer’s lactate solution
Compatible + Glucose 5%
injectionVincristine sulfate Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene NaCl 0,9% or Glucose 5% 0,02 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 4°C Protect from light
21 Day
Compatible + Sodium chloride 0,9%
Compatible + Glucose 5%
Compatible + Ringer’s lactate solution
Compatible + Ringer’s lactate solution
injectionVindesine sulfate Anticancer drug
Stability in solutions Glass Water for Injection 1 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene Sodium chloride 0,9% 0,02 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene Glucose 5% 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene Glucose 5% 0,02 mg/ml 4°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 25°C Protect from light
21 Day
Stability in solutions Polypropylene Ringer’s lactate solution 0,02 mg/ml 4°C Protect from light
21 Day
Compatible + Sodium chloride 0,9%
Compatible + Glucose 5%
Compatible + Ringer’s lactate solution

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