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References   References 1062  
Type : Journal
Web link : https://doi.org/10.1016/S0378-5173(96)04813-2
Research teams : Ghent - laboratory of Pharmaceutical technology, State University of Gent
Authors : Vermeire A, Remon JP.
Title : The stability of morphine and the stability of concentrated morphine solutions in glass, polypropylene syringes and PVC containers.
Reference : Int J Pharm ; 146: 213-223. 1997
Level of Evidence : 
Level of evidence A
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
List of drugs
injectionMorphine hydrochloride Analgesic
Factors which affect stability Temperature Reduction[>30 mg/ml] Induces Precipitation
Stability in solutions Glass Water for Injection 30 mg/ml 22°C Protect from light
90 Day
Stability in solutions Glass NaCl 0,9% or Glucose 5% 30 mg/ml 22°C Protect from light
90 Day
Stability in solutions Polypropylen Syringe Water for Injection 30 mg/ml 22°C Protect from light
90 Day
Stability in solutions Polypropylen Syringe NaCl 0,9% or Glucose 5% 30 mg/ml 22°C Protect from light
90 Day
Compatible + Sodium chloride 0,9%
Compatible + Glucose 5%
  Mentions Légales