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08/11/2024
細胞増殖抑制薬   Fluorouracil  
注射薬
溶媒内の安定性 混合時の安定性 安定性に影響する因子 互換性 投与経路 引用文献 PDF
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商品名、賦形剤は国、製薬会社ごとに異なることがあります

Acoflut メキシコ
Adrucil アメリカ
Eurofluor ドイツ
Fivocil インド
Fivoflu インド, メキシコ
Fluorouracil アメリカ, イギリス, イタリア, オランダ, オーストリア, カナダ, ギリシア, スイス, スペイン, セルビア, デンマーク, トルコ, ノルウェー, ハンガリー, フィンランド, ブラジル, ベルギー, ポルトガル, ポーランド, 南アフリカ共和国
Fluorouracile フランス
Flurablastin スウェーデン, デンマーク, ノルウェー, フィンランド
Fluracedyl オランダ, ベルギー, マレーシア, ルクセンブルグ
Fluroblastin 南アフリカ共和国
Fluroblastine ベルギー
Flurox メキシコ
Neofluor ドイツ
Neoflur エジプト
Oncofu アルゼンチン
Ribofluor ドイツ
Triosules アルゼンチン
引用文献   注射薬   引用文献 : Fluorouracil  
形式 出版物
3 雑誌 Trissel LA, Martinez JF.
Compatibility of amifostine with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 2208-2212.
5 雑誌 Stiles ML, Allen LV Jr, Prince SJ.
Stability of deferoxamine mesylate, floxuridine, fluorouracil, hydromorphone hydrochloride, lorazepam, and midazolam hydrochloride in polypropylene infusion-pump syringes.
Am J Health-Syst Pharm 1996 ; 53: 1583-1588.
33 雑誌 Baud-Camus F, Crauste-Manciet S, Klein E, Richard L, Brossard D.
Stability of fluorouracil in polypropylene syringes and ethylene vinyl acetate infusion-pump reservoirs.
Am J Health-Syst Pharm 1996 ; 53: 1457-1458.
39 雑誌 Farhang-Asnafi S, Callaert S, Barre J, Tillement JP, Thebault A.
Influence of intravenous admixtures on the stability of the new solution of 5-fluorouracil.
J Pharm Clin 1997 ; 16: 45-48.
40 雑誌 Dine T, Lebegue S, Benaji B, Gressier B, Segard V, Goudaliez F, Luyckx M, Brunet C, Mallevais ML, Kablan J, Cazin M, Cazin JC.
Stability and compatibility studies of four cytostatic agents (fluorouracil, dacarbazine, cyclophosphamide and ifosfamide) with PVC infusion bags.
Pharm Sci Communications 1994 ; 4: 97-101.
49 雑誌 Trissel LA, Martinez JF.
Compatibility of granisetron hydrochloride with selected alkaline drugs.
Am J Health-Syst Pharm 1995 ; 52: 208.
57 雑誌 Mayron D, Gennaro AR.
Stability and compatibility of granisetron hydrochloride in IV solutions and oral liquids and during simulated Y-site injection with selected drugs.
Am J Health-Syst Pharm 1996 ; 53: 294-304.
81 雑誌 Trissel LA, Martinez JF.
Compatibility of piperacillin sodium plus tazobactam with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1994 ; 51: 672-678.
84 雑誌 Trissel LA, Martinez JF.
Visual, turbidimetric, and particle-content assessment of compatibility of vinorelbine tartrate with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1994 ; 51: 495-499.
85 雑誌 Trissel LA, Bready BB.
Turbidimetric assessment of the compatibility of taxol with selected other drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 1716-1719.
91 雑誌 Lober CA, Dollard PA.
Visual compatibility of gallium nitrate with selected drugs during Y-site injection.
Am J Hosp Pharm 1993 ; 50: 1208-1210.
99 雑誌 Trissel LA, Martinez JF.
Compatibility of aztreonam with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1995 ; 52: 1086-1090.
110 雑誌 Vincke BJ, Verstraeten AE, El Eini DID, Mc Carthy TM.
Extended stability of 5-fluorouracil and methotrexate solutions in PVC containers.
Int J Pharm 1989 ; 54: 181-189.
138 雑誌 Corbrion V, Crauste-Manciet S, Allain P, Brossard D.
Precipitation of fluorouracil in elastomeric infusers with a polyisoprene reservoir and in polypropylene syringes with an elastomeric joint.
Am J Health-Syst Pharm 1997 ; 54: 1845-1848.
142 雑誌 Rochard EB, Barthes DMC, Courtois PY.
Stability of fluorouracil, cytarabine, or doxorubicin hydrochloride in ethylene vinylacetate portable infusion-pump reservoirs.
Am J Hosp Pharm 1992 ; 49: 619-623.
153 雑誌 Wang DP, Chang LC, Lee DK.
Stability of fluorouracil-metoclopramide hydrochloride admixture.
Am J Health-Syst Pharm 1995 ; 52: 98-99.
155 雑誌 Trissel LA, Martinez JF, Xu QA.
Incompatibility of fluorouracil with leucovorin calcium or levoleucovorin calcium.
Am J Health-Syst Pharm 1995 ; 52: 710-715.
156 雑誌 Barberi-Hayob M, Merlin JL, Vigneron M, Conroy T.
Addition of heparin in 5-fluorouracil solution for portal vein infusion has no influence on its stability under clinically relevant conditions.
Anticancer Drugs 1995 ; 6: 163-164.
163 雑誌 Sewell GJ, Allsopp M, Collinson MP, Tyrrell C, Prentice AJ, Copplestone JA.
Stability studies on admixtures of 5-fluorouracil with carboplatin and 5-fluorouracil with heparin for administration in continuous infusion regimens.
J Clin Pharm Ther 1994 ; 19: 127-133.
169 雑誌 Trissel LA, Martinez JF.
Physical compatibility of melphalan with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1993 ; 50: 2359-2363.
182 雑誌 Trissel LA, Gilbert DL, Martinez JF.
Compatibility of granisetron hydrochloride with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 56-60.
244 雑誌 Trissel LA, Martinez JF.
Compatibility of filgrastim with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1907-1913.
249 雑誌 Trissel LA, Martinez JF.
Compatibility of thiotepa (lyophilized) with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1996 ; 53: 1041-1045.
251 雑誌 Trissel LA, Gilbert DL, Martinez JF.
Compatibility of doxorubicin hydrochloride liposome injection with selected other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 2708-2713.
300 雑誌 Trissel LA, Gilbert DL, Martinez JF.
Compatibility of propofol injectable emulsion with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1287-1292.
301 雑誌 Trissel LA, Gilbert DL, Martinez JF, Baker MB, Walter WV, Mirtallo JM.
Compatibility of parenteral nutrient solutions with selected drugs during simulated Y-site administration.
Am J Health-Syst Pharm 1997 ; 54: 1295-1300.
307 雑誌 Trissel LA, Martinez JF.
Compatibility of allopurinol sodium with selected drugs during simulated Y-site administration.
Am J Hosp Pharm 1994 ; 51: 1792-1799.
334 雑誌 Trissel LA, Tramonte SM, Grilley BJ.
Visual compatibility of ondansetron hydrochloride with selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 988-992.
335 雑誌 Trissel LA, Bready BB, Kwan JW, Santiago NM.
Visual compatibility of sargramostim with selected antineoplasic agents, anti-infectives, or other drugs during simulated Y-site injection.
Am J Hosp Pharm 1992 ; 49: 402-406.
411 雑誌 Woloschuk DMM, Wermeling JR, Pruemer JM.
Stability and compatibility of fluorouracil and mannitol during simulated Y-site administration.
Am J Hosp Pharm 1991 ; 48: 2158-2160.
413 雑誌 Stewart CF, Fleming RA.
Compatibility of cisplatin and fluorouracil in 0.9% sodium chloride injection.
Am J Hosp Pharm 1990 ; 47: 1373-1377.
415 雑誌 Stiles ML, Allen LV, Tu YH.
Stability of fluorouracil administered through four portable infusion pumps.
Am J Hosp Pharm 1989 ; 46: 2036-2040.
431 雑誌 McRae MP, King JC.
Compatibility of antineoplastic, antibiotic and corticosteroid drugs in intravenous admixtures.
Am J Hosp Pharm 1975 ; 33: 1010-1013.
484 雑誌 Northcott M, Allsopp MA, Powell H, Sewell GJ.
The stability of carboplatin, diamorphine, 5-fluorouracil and mitozantrone infusions in an ambulatory pump under storage and prolonged “in use” conditions.
J Clin Pharm Ther 1991 ; 16: 123-129.
492 雑誌 Trissel LA, Parks NPT, Santiago NM.
Visual compatibility of fludarabine phosphate with antineoplastic drugs, anti-infectives, and other selected drugs during simulated Y-site injection.
Am J Hosp Pharm 1991 ; 48: 2186-2189.
513 雑誌 Xu QA, Trissel LA, Martinez JF.
Stability and compatibility of fluorouracil with morphine sulfate and hydromorphone hydrochloride.
Ann Pharmacotherapy 1996 ; 30: 756-761.
514 雑誌 Xu QA, Trissel LA, Martinez JF.
Rapid loss of fentanyl citrate admixed with fluorouracil in polyvinyl chloride containers.
Ann Pharmacotherapy 1997 ; 31: 297-302.
763 雑誌 Cohen MH, Jonhson-Early A, Hood MA, McKenzie M, Citron ML, Jaffe N, Krasnow SH.
Drug precipitation within IV tubing : A potential hazard of chemotherapy administration.
Cancer Treat Rep 1985 ; 69: 1325-1326.
840 雑誌 Biondi L, Nairn JG.
Stability of 5-fluorouracil and flucytosine in parenteral solutions.
Can J Hosp Pharm 1986 ; 39: 60-66.
842 雑誌 Pinguet F, Favre G, Canal P, Pujol A, Soula G.
Stability of 5-fluorouracil to heat and light.
J Pharm Clin 1990 ; 9: 155-158.
844 雑誌 Rochard E, Chapelle G, Bouquet S, Barthes D, Courtois PH.
Stability of fluorouracil and cytarabine in ethylvinylacetate containers.
J Pharm Clin 1989 ; 9: 31-35.
905 雑誌 Trissel LA, Martinez JF.
Screening teniposide for Y-site physical incompatibilities.
Hosp Pharm 1994 ; 29: 1010-1017.
921 雑誌 Trissel LA, Gilbert DL, Martinez JF.
Incompatibility and compatibility of amphotericin B cholesteryl sulfate complex with selected other drugs during simulated Y-site administration.
Hosp Pharm 1998 ; 33: 284-292.
1026 雑誌 Mayron D, Gennaro AR.
Stability and compatibility of topotecan hydrochloride with selected drugs.
Am J Health-Syst Pharm 1999 ; 56: 875-881.
1040 雑誌 Quebbeman EJ, Hamid AAR, Hoffman NE, Ausman RK.
Stability of fluorouracil in plastic containers used for continuous infusion at home.
Am J Hosp Pharm 1984 ; 41: 1153-1156.
1228 雑誌 Allen LV, Stiles ML.
Compatibility of various admixtures at Y-injection sites of intravenous administration sets. Part2.
Am J Hosp Pharm 1981 ; 38: 380-381.
1325 雑誌 Hardin TC, Clibon U, Page CP, Cruz AB.
Compatibility of 5-fluorouracil and total nutrition solutions.
JPEN 1982 ; 6: 163-165.
1410 雑誌 Trissel LA, Martinez JF, Simmons M.
Compatibility of etoposide phosphate with selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 141-145.
1415 雑誌 Trissel L.A, Gilbert D.L, Martinez J.F, Baker M.B, Walter W.V, Mirtallo J.M.
Compatibility of medications with 3-in-1 parenteral nutrition admixtures.
JPEN 1999 ; 23: 67-74.
1423 雑誌 Trissel LA, Martinez JF, Gilbert DL.
Compatibility of gemcitabine hyrochloride with 107 selected drugs during simulated Y-site injection.
J Am Pharm Assoc 1999 ; 39: 514-518.
1475 雑誌 Martel P, Petit I, Pinguet F, Poujol S, Astre C, Fabbro M.
Long-term stability of 5-fluorouracil stored in PVC bags and in ambulatory pump reservoirs.
J Pharm Biomed Anal 1996 ; 14: 395-399.
1501 雑誌 Beitz C, Bertsch T, Hannak D, Schrammel W, Einberger C, Wehling M.
Compatibility of plastics with cytotoxic drug solutions - comparison of polyethylene with other container materials.
Int J Pharm 1999 ; 185: 113-121.
1520 実験 Etude de stabilité des médicaments en Ecoflac®
B Braun 2001
1625 雑誌 Trissel LA, Saenz C, Williams YW, Ingram D.
Incompatibilities of lansoprazole injection with other drugs during simulated Y-site coadministration.
Int J Pharm Compound 2001 ; 5: 314-321.
1812 雑誌 Fuhrman LC, Godwin DA, Davis RA.
Stability of 5-fluorouracil in an extemporaneously compounded ophtalmic solution.
Int J Pharm Compound 2000 ; 4, 4: 320-323.
1817 雑誌 Roberts S, Sewell GJ.
Stability and compatibility of 5-fluorouracil infusions in the Braun Easypump®.
J Oncol Pharm Practice 2003 ; 9: 109-112.
1842 雑誌 Sadjack A, Wintersteiger R.
Compatibility of morphin, baclofen, floxuridine and fluorouracil in an implantable infusion pump.
Arzneimittel Forschung 1995 ; 45: 93-98.
1925 雑誌 Trissel LA , Williams KY, Gilbert DL.
Compatibility screening of linezolid injection during simulated Y-site administration with other drugs and infusion solutions.
J Am Pharm Assoc 2000 ; 40: 515-519.
1953 雑誌 Trissel LA, Saenz CA, Ogundele AB, Ingram DS.
Physical compatibility of pemetrexed disodium with other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2004 ; 61: 2289-2293.
1982 雑誌 Trissel LA, Ogundele AB.
Compatibility of anidulafungin with other drugs during simulated Y-site administration.
Am J Health-Syst Pharm 2005 ; 62: 834-837.
1998 雑誌 Allwood MC.
Fluorouracil precipitate.
Am J Health-Syst Pharm 1998 55: 1315-1316.
2009 雑誌 Trissel LA, Zhang Y.
Physical and chemical stability of palonosetron hydrochloride with fluorouracil and with gemcitabine hydrochloride during simulated Y-site administration.
Int J Pharm Compound 2005 ; 2005, 9, 4: 320-322.
2130 雑誌 Lokiec F, Amirault P, Bonnans H, Gauzan MF, Sauvage N, Santoni J.
Stabilité du mélange 5-fluoro-uracil-acide fonique : influence des concentrations, du contenant et de la forme de l’acide folinique.
Bull Cancer 1999 ; 86, 11: 946-954.
2181 雑誌 Milano G, Renée N.
Etude de compatibilité physicochimique 5- fluoro-uracile (nouvelle préparation française) - acide folinique.
Bull Cancer 1995 ; 82: 189-195.
2262 雑誌 Brammer MK, Chan P, Heatherly K, Trusley C, Kupiec TC, Trissel LA, Psathas PA, Gilmor T, Schaufelberger D.
Compatibility of doripenem with other drugs during simulated Y-site administratioN
Am J Health-Syst Pharm 2008 ; 65: 1261-1265.
2323 雑誌 Galanti L, Lebitasy M.P, Hecq J.D, Cadrobbi J, Vanbeckbergen D, Jamart J.
Long-Term Stability of 5-Fluorouracil in 0.9% Sodium Chloride after Freezing, Microwave Thawing, and Refrigeration
Can J Hosp Pharm 2009 ; 62, 1
3369 実験 Levofolinate de sodium Medac - Résumé des caractéristiques du produits
MEDAC France 2011
3474 実験 Fluorouracil - Summary of Product Characteristics
Accord Healthcare Limited 2009
3531 実験 Morphine sulphate 10 mg/mL injection BP – Summary of Product Characteristics
Wockhardt 2014
3574 実験 Ondansetron - Résumé des caractéristiques du produit
Accord Healthcare France SAS 2013
3578 実験 Cisplatin - Summary of Product Characteristics
Accord Healthcare 2011
3580 実験 Cytarabine Accord - Résumé des caractéristiques du produit
Accord Healthcare France 2016
3634 実験 Oxaliplatine (Oxaliplatine Accord®) - Résumé des caractéristiques du produit
Accord Healthcare 2011
3637 実験 Methotrexate (Methotrexate solution for injection®) - Summary of Product Characteristics
Hameln Pharmaceuticals 2014
3645 実験 Doxorubicin - Summary of Product Characteristics
Accord Healthcare 2014
3670 雑誌 Sewell G, Massimini M.
Studies on the stability and compatibility of cytotoxic drug infusion with the Tevadaptor system.
EJOP 2014 ; 8, 3: 26-30.
3873 雑誌 Tan X, Hu J.
Incompatibility between irinotecan and fluorouracil injections
Am J Health-Syst Pharm 2016 ; 73:755.
3948 雑誌 Bouchoud L, Fonzo-Christe C, Klingm?ller M, Bonnabry P .
Compatibility of Intravenous Medications With Parenteral Nutrition - In Vitro Evaluation.
JPEN 2012 ;30. 416?424.
4568 雑誌 Closset M,Onorati S, Colsoul M.L,Goderniaux N,Bihin B, Jamart J, Soumoy L, Hecq J.D, Odou P, Galanti L.
Long-term physico-chemical stability of 5-fluorouracile at standardised rounded doses (SRD) in MyFuser® portable infusion pump.
Journal of Chemotherapy 2021
4735 雑誌 Closset M, Onorati S, Colsoul M-L, Goderniaux N, Bihin B, Jamart J, Soumoy L, Hecq J-D, Odou P, Galanti L.
Long-term physicochemical stability of 5-fluorouracil at selected standardised rounded doses in polyolefin bags.
J Oncol Pharm Practice 2023 ;29,8:1878 - 1883
4759 ポスター Ma NH, Charbonneau LF, Law S, Walker S.
Stability of 5-fluorouracil at 4°C, 25°C, and 33°C stored in NiproSureFuser+ Ambulatory Balloon Infusers.
Sunnybrook Healt Science Centre 2023

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