Last update :
08/05/2024
Antidote   Hydroxocobalamin  
Injection
Stability in solutions Stability of mixtures Factors which affect stability Compatibility Route of administration References Pdf
   Chemical structure  

Tradename   Tradename     

Trade names are indicative and excipients composition can be different depending on the country and manufacturers

Cyanokit Austria, Belgium, Canada, Denmark, Finland, France, Germany, Great Britain, Greece, Hungary, Italy, Netherlands, Norway, Poland, Spain, Sweden
Hydroxocobalamin Spain
Compatibility   Injection   Compatibility : Hydroxocobalamin              
This screen indicates the compatibilities or incompatibilities with, in this case, the type of incompatibility (precipitation, color change, modification of an emulsion, etc.). The compatibilities shown here are mostly physical only, with the chemical stability of each molecule rarely being assessed. The evaluation of these mixtures was studied to consider the possibility of Y-site administration to the patient. These data cannot be used for making mixtures in advance in bags or syringes. This type of information is available in the screen "Stability in mixture ».
Compound Solvent References
Chemical instability Incompatible
Injection Hydroxocobalamin
NaHCO3 3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Adenosin
3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Amiodarone hydrochloride
3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Ascorbic acid
3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Atropine sulfate
3932
Immediate precipitation Incompatible
Injection Hydroxocobalamin
Injection Diazepam
3932
Immediate precipitation Incompatible
Injection Hydroxocobalamin
Injection Dobutamine hydrochloride
3932
Immediate precipitation Incompatible
Injection Hydroxocobalamin
Injection Dopamine hydrochloride
3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Epinephrine hydrochloride
3932
Immediate precipitation Incompatible
Injection Hydroxocobalamin
Injection Fentanyl citrate
3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Ketamine hydrochloride
3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Lidocaine hydrochloride
3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Midazolam hydrochloride
3932
Immediate precipitation Incompatible
Injection Hydroxocobalamin
Injection Nitroglycerin
3932
Immediate precipitation Incompatible
Injection Hydroxocobalamin
Injection Pentobarbital sodium
3932
Immediate precipitation Incompatible
Injection Hydroxocobalamin
Injection Phenytoin sodium
3932
Immediate precipitation Incompatible
Injection Hydroxocobalamin
Injection Propofol
3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Sodium bicarbonate
3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Sodium thiosulfate
3932
Chemical instability Incompatible
Injection Hydroxocobalamin
Injection Suxamethonium chloride
3932
Immediate precipitation Incompatible
Injection Hydroxocobalamin
Injection Thiopental sodium
3932

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