Last update :
18/04/2024
References   References 4003  
Type : Journal
Web link : https://ejhp.bmj.com/content/25/3/157

Research teams : Incheon - Yonsei University, College of Pharmacy
Authors : Kim J, Chung J, Park S, Jung S, Kang D.
Title : Evaluation of the physicochemical and biological stability of reconstituted and diluted SB2 (infliximab).
Reference : EJHP ; 25, 3: 157-164. 2017

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Particle counting Protein: Size Exclusion Chromatography Turbidimetry 
Chemical stability : 
Other methods : 
PH measurement Measurement of osmolality 
Comments : 
Proteins: biological activity by enzymatic technique
Proteins: biological activity by cell culture

List of drugs
InjectionInfliximab Immunosuppressant
Stability in solutions Glass Water for Injection 10 mg/ml 25°C Protect from light
7 Day
Biosimilar
Stability in solutions Glass Water for Injection 10 mg/ml 5°C Protect from light
60 Day
Biosimilar
Stability in solutions Polyethylene Sodium chloride 0,9% 0,96 mg/ml 25°C Protect from light
7 Day
Biosimilar
Stability in solutions Polyethylene Sodium chloride 0,9% 0,96 mg/ml 5°C Protect from light
7 Day
Biosimilar
Stability in solutions Polyethylene Sodium chloride 0,9% 1,2 mg/ml 25°C Protect from light
7 Day
Biosimilar
Stability in solutions Polyethylene Sodium chloride 0,9% 1,2 mg/ml 5°C Protect from light
7 Day
Biosimilar
Stability in solutions Polyethylene Sodium chloride 0,9% 1,6 mg/ml 25°C Protect from light
7 Day
Biosimilar
Stability in solutions Polyethylene Sodium chloride 0,9% 1,6 mg/ml 5°C Protect from light
7 Day
Biosimilar

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