Last update :
28/04/2024
References   References 3971  
Type : Journal
Web link : http://www.ijpc.com/Abstracts/Abstract.cfm?ABS=4298

Research teams : Birmingham - Samford University, School of Pharmacy
Authors : Gorman G, Sokom S, Coward L, Arnold J J.
Title : Development and Application of a High-Performance Liquid Chromatography Stability-Indicating Assay for Beyond-Use Date Determination of Compounded Topical Gels Containing Multiple Active Drugs.
Reference : Int J Pharm Compound ; 21, 2 : 164-170. 2017

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
OintmentsAmitriptyline hydrochloride Antidepressant
OintmentsBaclofen Various
OintmentsGabapentine Antiepileptic
OintmentsKetoprofene Anti-inflammatory
OintmentsLidocaine hydrochloride Local anesthetic
Stability of mixtures
Not specified Propylene glycol >>
Lipoderm® >> 100 g
25°C Protect from light
Ointments Amitriptyline hydrochloride Powder ® = ? 2 g
Ointments Gabapentine Powder ® = ? 4 g
Ointments Ketoprofene Powder ® = ? 10 g
14 Day
Not specified Propylene glycol >>
Lipoderm® >> 100 g
25°C Protect from light
Ointments Amitriptyline hydrochloride Powder ® = ? 2 g
Ointments Gabapentine Powder ® = ? 6 g
Ointments Ketoprofene Powder ® = ? 10 g
Ointments Lidocaine hydrochloride Powder ® = ? 5 g
14 Day
Not specified Propylene glycol >>
Lipobase® >> 100 g
25°C Protect from light
Ointments Lidocaine hydrochloride Powder ® = ? 5 g
Ointments Ketoprofene Powder ® = ? 10 g
Ointments Gabapentine Powder ® = ? 6 g
Ointments Amitriptyline hydrochloride Powder ® = ? 2 g
28 Day
Not specified Propylene glycol >>
Lipobase® >> 100 g
25°C Protect from light
Ointments Ketoprofene Powder ® = ? 10 g
Ointments Gabapentine Powder ® = ? 4 g
Ointments Amitriptyline hydrochloride Powder ® = ? 2 g
49 Day
Not specified Propylene glycol 
Lipoderm® >> 100 g
25°C Protect from light
Ointments Baclofen Powder ® = ? 5 g
Ointments Ketoprofene Powder ® = ? 5 g
120 Day
Not specified Propylene glycol >>
Lipobase® >> 100 g
25°C Protect from light
Ointments Baclofen Powder ® = ? 5 g
Ointments Ketoprofene Powder ® = ? 5 g
120 Day

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