Last update :
28/04/2024
References   References 3925  
Type : Journal
Web link : http://www.em-consulte.com/article/1098429/article/long-term-stability-of-dexamethasone-and-alizaprid

Research teams : Mont Godinne - Drug Stability Research Group (DSRG) - CHU UCL NAMUR, site de Godinne
Authors : Simar J, Godet M, Hecq J.-D, Closset M, Gillet P, Langhendries C, Bihin B, Jamart J, Galanti L.
Title : Long-term stability of dexamethasone and alizapride or ondansetron in sodium chloride 0.9% polyolefin bag at 5±3 C.
Reference : Ann Pharm Fr ; 75, 1 : 30-39. 2016

Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
High Performance Liquid Chromatography - Diode Array detector (HPLD-DAD)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
No comments for the degradation products

List of drugs
InjectionAlizapride hydrochloride Antiemetic
Compatible 1 mg/ml + InjectionDexamethasone sodium phosphate 0.1 mg/ml + Sodium chloride 0,9%
InjectionDexamethasone sodium phosphate Anti-inflammatory
Compatible 0.1 mg/ml + InjectionAlizapride hydrochloride 1 mg/ml + Sodium chloride 0,9%
Compatible 0.1 mg/ml + InjectionOndansetron hydrochloride 0.08 mg/ml + Sodium chloride 0,9%
InjectionOndansetron hydrochloride Antiemetic
Compatible 0.08 mg/ml + InjectionDexamethasone sodium phosphate 0.1 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyolefine Sodium chloride 0,9% 2-8°C Not specified
Injection Alizapride hydrochloride 1 mg/ml
Injection Dexamethasone sodium phosphate 0.1 mg/ml
30 Day
Polyolefine Sodium chloride 0,9% 2-8°C Not specified
Injection Ondansetron hydrochloride 0.08 mg/ml
Injection Dexamethasone sodium phosphate 0.1 mg/ml
30 Day

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