Last update :
28/04/2024
References   References 3779  
Type : Journal

Research teams : Ann Arbor - University of Michigan, College of Pharmacy
Authors : Kintzel P.E, Zhao T, Wen B, Sun D.
Title : Stability of i.v. admixture containing metoclopramide, diphenhydramine hydrochloride, and dexamethasone sodium phosphate in 0.9% sodium chloride injection
Reference : Am J Health-Syst Pharm ; 71:2061-2065 2014

Level of Evidence : 
Level of evidence D
Physical stability : 
Chemical stability : 
High Performance Liquid Chromatography - mass spectrometry (HPLC-MS)
Stability defined as 90% of the initial concentration
Other methods : 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
Increased concentration unexplained
No visual inspection
Results with high coefficient of variation or not provided, or lack of duplicate analysis of each point
No comments for the degradation products

List of drugs
InjectionDexamethasone sodium phosphate Anti-inflammatory
InjectionDiphenhydramine hydrochloride Antihistamine (H1)
InjectionMetoclopramide hydrochloride Antiemetic
Stability of mixtures
Not specified Sodium chloride 0,9% 25°C Light
Injection Metoclopramide hydrochloride 1,6 mg/ml
Injection Diphenhydramine hydrochloride 2 mg/ml
Injection Dexamethasone sodium phosphate 0,16 mg/ml
48 Hour

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