Last update :
18/04/2024
References   References 3728  
Type : Journal
Web link : http://www.ajhp.org/content/71/15/1288.abstract

Research teams : Marseille - La Timone University Teaching Hospital, Pharmacy Department
Authors : Correard F, Savry A, Gauthier-Villano L, Pisano P, Pourroy B.
Title : Visual compatibility of defibrotide with selected drugs during simulated Y-site administration.
Reference : Am J Health-Syst Pharm ; 71: 1288-1291. 2014

Level of Evidence : 
Physical stability : 
Chemical stability : 
Other methods : 
Comments : 

List of drugs
InjectionAciclovir sodium Antiviral
Compatible 10 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionAlizapride hydrochloride Antiemetic
Compatible 0.96 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionAmikacin sulfate Antibiotic
Incompatible 5 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionAmoxicillin sodium Antibiotic
Compatible 40 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionAmphotericin B liposomale Antifungal
Compatible 2 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionCaspofungin acetate Antifungal
Compatible 0.4 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionCeftazidime Antibiotic
Compatible 80 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionCeftriaxone disodium Antibiotic
Compatible 100 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionCiclosporin Immunosuppressant
Compatible 1.27 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionCiprofloxacin lactate Antibiotic
Compatible 2 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionClonazepam Antiepileptic
Compatible 0.02 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionClonidine hydrochloride Antihypertensive
Compatible 0.0024 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionCo-trimoxazole Antibiotic
Compatible 0.64/3.2 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionDeferoxamine mesylate Chelator
Compatible 6.7 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionDefibrotide Anticoagulant
Compatible 8 mg/ml + InjectionAciclovir sodium 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionAlizapride hydrochloride 0.96 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + InjectionAmikacin sulfate 5 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionAmoxicillin sodium 40 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionAmphotericin B liposomale 2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionCaspofungin acetate 0.4 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionCeftazidime 80 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionCeftriaxone disodium 100 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionCiclosporin 1.27 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionCiprofloxacin lactate 2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionClonazepam 0.02 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionClonidine hydrochloride 0.0024 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionCo-trimoxazole 0.64/3.2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionDeferoxamine mesylate 6.7 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionFluconazole 2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionFoscarnet sodium 24 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionFosfomycin 40 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + InjectionFurosemide 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionGanciclovir sodium 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionHeparin sodium 373 UI/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionHuman albumin 200 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionHydrocortisone sodium succinate 1.9 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionHydroxyzine dihydrochloride 0.79 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionImipenem - cilastatin sodium 9.94/9.94 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + InjectionImipenem - cilastatin sodium 9.94/9.94 mg/ml + Glucose 5%
Compatible 8 mg/ml + InjectionMesna 4.76 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + InjectionMethylprednisolone sodium succinate 10 mg/ml + Glucose 5%
Compatible 8 mg/ml + InjectionMethylprednisolone sodium succinate 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionMetronidazole 5 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + InjectionMidazolam hydrochloride 5 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + InjectionMycophenolate mofetil 11.9 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionNalbuphine hydrochloride 2 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionNaloxone hydrochloride 0.4 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionNefopam 5 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + InjectionNicardipine hydrochloride 0.5 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionOndansetron hydrochloride 0.16 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionPantoprazole sodium 1.6 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionParacetamol 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionPhloroglucinol 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionTeicoplanine 125 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + InjectionTobramycin sulfate 10 mg/ml + Sodium chloride 0,9%
Compatible 8 mg/ml + InjectionTranexamic acid 100 mg/ml + Sodium chloride 0,9%
Incompatible 8 mg/ml + InjectionVancomycin hydrochloride 10.4 mg/ml + Sodium chloride 0,9%
InjectionFluconazole Antifungal
Compatible 2 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionFoscarnet sodium Antiviral
Compatible 24 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionFosfomycin Antibiotic
Compatible 40 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionFurosemide Diuretic
Incompatible 10 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionGanciclovir sodium Antiviral
Compatible 10 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionHeparin sodium Anticoagulant
Compatible 373 UI/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionHuman albumin Various
Compatible 200 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionHydrocortisone sodium succinate Anti-inflammatory
Compatible 1.9 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionHydroxyzine dihydrochloride Anxiolytic
Compatible 0.79 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionImipenem - cilastatin sodium Antibiotic
Compatible 9.94/9.94 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
Incompatible 9.94/9.94 mg/ml + InjectionDefibrotide 8 mg/ml + Glucose 5%
InjectionMesna Cytoprotective
Compatible 4.76 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionMethylprednisolone sodium succinate Anti-inflammatory
Compatible 10 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
Incompatible 10 mg/ml + InjectionDefibrotide 8 mg/ml + Glucose 5%
InjectionMetronidazole Antiparasitic
Compatible 5 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionMidazolam hydrochloride Anxiolytic
Incompatible 5 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionMycophenolate mofetil Immunosuppressant
Incompatible 11.9 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionNalbuphine hydrochloride Antidote
Compatible 2 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionNaloxone hydrochloride Antidote
Compatible 0.4 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionNefopam Analgesic
Compatible 5 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionNicardipine hydrochloride Vasodilator
Incompatible 0.5 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionOndansetron hydrochloride Antiemetic
Compatible 0.16 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionPantoprazole sodium Proton pump inhibitor
Compatible 1.6 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionParacetamol Analgesic
Compatible 10 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionPhloroglucinol  Antispasmodic
Compatible 10 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionTeicoplanine Antibiotic
Compatible 125 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionTobramycin sulfate Antibiotic
Incompatible 10 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionTranexamic acid Anti-bleeding
Compatible 100 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%
InjectionVancomycin hydrochloride Antibiotic
Incompatible 10.4 mg/ml + InjectionDefibrotide 8 mg/ml + Sodium chloride 0,9%

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