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References   References 3438  
Type : Journal
Web link : http://www.sciencedirect.com/science/article/pii/S0731708513002008
Research teams : Tours - Faculté de pharmacie, Innovation moléculaire et thérapeutique
Authors : Respaud R, Quenum L, Plichon C, Tournamille J.F, Gyan E, Antier D, Viaud-Massuard M.C.
Title : A stability-indicating, ion-pairing, reversed-phase liquid chromatography method for studies of daunorubicin degradation in i.v. infusion fluids.
Reference : J Pharm Biomed Anal ; 83 : 164-170. 2013
Level of Evidence : 
Level of evidence A+
Physical stability : 
Visual examination Turbidimetry 
Chemical stability : 
Stability defined as 95% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
High Performance Liquid Chromatography - Evaporative Light Scattering detector (HPLC-ELSD)
Other methods : 
PH measurement 
Comments : 
Degradation products not observed in real conditions
List of drugs
InjectionDaunorubicin hydrochloride Anticancer drug
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,4 >> 3 mg/ml 22°C Protect from light
14 Day
Stability in solutions Polyolefine NaCl 0,9% or Glucose 5% 0,4 >> 3 mg/ml 4°C Protect from light
14 Day
  Mentions Légales