Last update :
28/04/2024
References   References 3434  
Type : Journal
Web link : http://www.cjhp-online.ca/index.php/cjhp/article/view/1253

Research teams : Vancouver - Children\'s and Women\'s Health Center of British Columbia
Authors : Kistner C, Ensom M.H.H, Decarie D, Lauder G, Carr R.R.
Title : Compatibility and Stability of Morphine Sulphate and Naloxone Hydrochloride in 0.9% Sodium Chloride for Injection.
Reference : Can J Hosp Pharm ; 66, 3 : 167-170. 2013

Level of Evidence : 
Level of evidence D
Physical stability : 
Visual examination 
Chemical stability : 
Stability defined as 90% of the initial concentration
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed
Imperfect separation of the internal standard from the product under study or its degradation products, or understudied
No comments for the degradation products

List of drugs
InjectionMorphine sulfate Analgesic
Compatible 1 mg/ml + InjectionNaloxone hydrochloride 0,004 >> 0,025 mg/ml + Sodium chloride 0,9%
InjectionNaloxone hydrochloride Antidote
Compatible 0,004 >> 0,025 mg/ml + InjectionMorphine sulfate 1 mg/ml + Sodium chloride 0,9%
Stability of mixtures
Polyvinyl chloride Sodium chloride 0,9% 22°C Not specified
Injection Morphine sulfate 1 mg/ml
Injection Naloxone hydrochloride 0.004 mg/ml
72 Hour
Polyvinyl chloride Sodium chloride 0,9% 22°C Not specified
Injection Morphine sulfate 1 mg/ml
Injection Naloxone hydrochloride 0,025 mg/ml
72 Hour
Polyvinyl chloride Sodium chloride 0,9% 22°C Not specified
Injection Morphine sulfate 1 mg/ml
Injection Naloxone hydrochloride 0,0125 mg/ml
72 Hour
Polyvinyl chloride Sodium chloride 0,9% 4°C Not specified
Injection Morphine sulfate 1 mg/ml
Injection Naloxone hydrochloride 0,025 mg/ml
30 Day
Polyvinyl chloride Sodium chloride 0,9% 4°C Not specified
Injection Morphine sulfate 1 mg/ml
Injection Naloxone hydrochloride 0,0125 mg/ml
30 Day
Polyvinyl chloride Sodium chloride 0,9% 4°C Not specified
Injection Morphine sulfate 1 mg/ml
Injection Naloxone hydrochloride 0,004 mg/ml
30 Day

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