Last update :
18/04/2024
References   References 1331  
Type : Journal

Research teams : Houston - University of Houston, College of Pharmacy
Authors : Das Gupta V, Steward KR.
Title : Chemical stabilities of lignocaine hydrochloride and phenylephrine hydrochloride in aqueous solution.
Reference : J Clin Hosp Pharm ; 11 : 449-452. 1986

Level of Evidence : 
Level of evidence C
Physical stability : 
Visual examination 
Chemical stability : 
High Performance Liquid Chromatography - ultraviolet detector (HPLC-UV)
Stability defined as 95% of the initial concentration
Other methods : 
PH measurement 
Comments : 
Stability indicating capability inadequately assessed

List of drugs
InjectionLidocaine hydrochloride Local anesthetic
Compatible 20 mg/ml + InjectionPhenylephrine hydrochloride 2.5 mg/ml + None
InjectionPhenylephrine hydrochloride Sympathomimetic
Compatible 2.5 mg/ml + InjectionLidocaine hydrochloride 20 mg/ml + None
Stability of mixtures
Not specified Water for injection + antibacterial 25°C Not specified
Injection Lidocaine hydrochloride 20 mg/ml
Injection Phenylephrine hydrochloride 2,5 mg/ml
66 Day

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