Type : |
Journal |
|
Research teams : |
Toledo - College of Pharmacy and Pharmaceutical Sciences, The University of Toledo |
Authors : |
Alexander KS, Sundar S, White DB, Dollimore D. |
Title : |
The Formulation Development and Stability of Spironolactone Suspension |
Reference : |
Int J Pharm Compound ; 1, 3: 195-199. 1997 |
|
Level of Evidence : |
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Physical stability : |
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Chemical stability : |
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Other methods : |
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Comments : |
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List of drugs
Spironolactone
|
![Diuretic Diuretic](./images/Picto.487.png) |
![Factors which affect stability Factors which affect stability](./images/Picto.594.jpg) |
PH |
PH 4.5 |
![Induces Induces](./images/Picto.659.gif) |
![Enhanced stability Enhanced stability](./images/Picto.650.gif) |
![Stability in solutions Stability in solutions](./images/Picto.591.jpg) |
![Not specified Not specified](./images/Picto.541.gif) |
![Tablets Tablets](./images/Picto.10386.jpg) |
600 mg ®= ? |
Carboxymethylcellulose |
900 mg |
Veegum® |
900 mg |
Methylparaben |
120 mg |
Propylparaben |
24 mg |
Propylene glycol |
1.2 ml |
Sorbitol |
70% 48 ml |
Sodium acetate |
350 mg |
Acetic acid |
36% 0.67 ml |
Sodium bisulfite |
120 mg |
Sodium edetate |
120 mg |
Sodium saccharin |
24 mg |
Pineapple aroma |
|
Distilled water |
>> 120 ml |
|
30°C |
![Protect from light Protect from light](./images/Picto.526.jpg) |
90 |
![Day Day](./images/Picto.542.gif) |
|
|
![Stability in solutions Stability in solutions](./images/Picto.591.jpg) |
![Not specified Not specified](./images/Picto.541.gif) |
![Tablets Tablets](./images/Picto.10386.jpg) |
600 mg ®= ? |
Carboxymethylcellulose |
900 mg |
Veegum® |
900 mg |
Methylparaben |
120 mg |
Propylparaben |
24 mg |
Propylene glycol |
1.2 ml |
Sorbitol |
70% 48 ml |
Sodium acetate |
350 mg |
Acetic acid |
36% 0.67 ml |
Sodium bisulfite |
120 mg |
Sodium edetate |
120 mg |
Sodium saccharin |
24 mg |
Pineapple aroma |
|
Distilled water |
>> 120 ml |
|
5°C |
![Protect from light Protect from light](./images/Picto.526.jpg) |
90 |
![Day Day](./images/Picto.542.gif) |
|
|
|
|